MK 677 Ibutamoren is classified as a non-peptide growth hormone secretagogue and mimics the growth hormone stimulating action of ghrelin. Ibutamoren is considered to be potent, long-acting, and available through oral administration. Clinically, it has been demonstrated to increase the endogenous release of growth hormone (GH) as well as insulin-like growth factor 1 (IGF-1) without the adverse increase of prolactin or cortisol often seen with GHRPs. Additionally, increases in lean body mass can be achieved while lowering LDL cholesterol. Studies have shown Ibutamoren stimulates brain regions involved with metabolic action, such as the hypothalamus and the pituitary. Ibutamoren may be effective in increasing both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty and osteoporosis in the elderly.
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